Allergen-Specific IgA Antibodies Block IgE-Mediated Activation of Mast Cells and Basophils

Allergen-Specific IgA Antibodies Block IgE-Mediated Activation of Mast Cells and Basophils

Mast cells and basophils have long been implicated in the pathogenesis of IgE-mediated hypersensitivity reactions. They express the high-affinity IgE receptor, FcϵRI, on their surface. Antigen-induced crosslinking of IgE antibodies bound to that receptor triggers a signaling cascade that results in...

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Bibliographic Details
Main Authors: Yasmeen S. El Ansari, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, Hans C. Oettgen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
basophils
basophil activation test
allergy
IgE
IgA
oral immunotherapy (OIT)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.881655/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.881655/full

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