Gemcitabine enhances pharmacokinetic exposure of the major components of Danggui Buxue Decoction in rat via the promotion of intestinal permeability and down-regulation of CYP3A for combination treatment of non-small cell lung cancer

Gemcitabine enhances pharmacokinetic exposure of the major components of Danggui Buxue Decoction in rat via the promotion of intestinal permeability and down-regulation of CYP3A for combination treatment of non-small cell lung cancer

AbstractContext Danggui Buxue Decoction (DBD), a traditional Chinese medicine formula, has the potential to enhance the antitumor effect of gemcitabine in non-small cell lung cancer (NSCLC) treatment by increasing gemcitabine’s active metabolites. However, whether gemcitabine affects the pharmacokin...

Full description

Bibliographic Details
Main Authors: Xin Xu, Xi-yang Sun, Ming Chang, Zhao-liang Hu, Ting-ting Cheng, Tai-jun Hang, Min Song
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Pharmaceutical Biology
Subjects:
Traditional Chinese medicine
bioavailability
metabolism
herb–drug interaction
Online Access:https://www.tandfonline.com/doi/10.1080/13880209.2023.2246500

Internet

https://www.tandfonline.com/doi/10.1080/13880209.2023.2246500

Similar Items