Potential Benefits of TNF Targeting Therapy in Blau Syndrome, a NOD2-Associated Systemic Autoinflammatory Granulomatosis

Potential Benefits of TNF Targeting Therapy in Blau Syndrome, a NOD2-Associated Systemic Autoinflammatory Granulomatosis

Blau syndrome is a systemic autoinflammatory granulomatous disease caused by mutations in the nucleotide-binding oligomerization domain 2 (NOD2) gene. NOD2 is an intracellular pathogen recognition receptor. Upon binding to muramyl dipeptide (MDP), NOD2 activates the NF-κB pathway, leading to the upr...

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Bibliographic Details
Main Authors: Tomoko Matsuda, Naotomo Kambe, Riko Takimoto-Ito, Yoko Ueki, Satoshi Nakamizo, Megumu K. Saito, Syuji Takei, Nobuo Kanazawa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
Blau syndrome
NOD2
granuloma
IFNγ
TNF
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.895765/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.895765/full

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