An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth

An in vivo genetic screen in Drosophila identifies the orthologue of human cancer/testis gene SPO11 among a network of targets to inhibit lethal(3)malignant brain tumour growth

Using transgenic RNAi technology, we have screened over 4000 genes to identify targets to inhibit malignant growth caused by the loss of function of lethal(3)malignant brain tumour in Drosophila in vivo. We have identified 131 targets, which belong to a wide range of gene ontologies. Most of these t...

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Bibliographic Details
Main Authors: Fabrizio Rossi, Cristina Molnar, Kazuya Hashiyama, Jan P. Heinen, Judit Pampalona, Salud Llamazares, José Reina, Tomomi Hashiyama, Madhulika Rai, Giulia Pollarolo, Ismael Fernández-Hernández, Cayetano Gonzalez
Format: Article
Language:English
Published: The Royal Society 2017-01-01
Series:Open Biology
Subjects:
l(3)mbt
drosophila
malignant growth
cancer testis antigens
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170156

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.170156

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