Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation

Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation

Tauopathies are a group of neurodegenerative diseases, which include frontotemporal dementia (FTD) and Alzheimer’s disease (AD), broadly defined by the development of tau brain aggregates. Both missense and splicing tau mutations can directly cause early onset FTD. Tau protein is a microtubule-assoc...

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Bibliographic Details
Main Authors: Yuxing Xia, Brach M. Bell, Justin D. Kim, Benoit I. Giasson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Neuroscience
Subjects:
tau protein
aggregation
microtubule
frontotemporal dementia
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2023.1181804/full

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https://www.frontiersin.org/articles/10.3389/fnins.2023.1181804/full

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