Fuzzy supertertiary interactions within PSD-95 enable ligand binding

Fuzzy supertertiary interactions within PSD-95 enable ligand binding

The scaffold protein PSD-95 links postsynaptic receptors to sites of presynaptic neurotransmitter release. Flexible linkers between folded domains in PSD-95 enable a dynamic supertertiary structure. Interdomain interactions within the PSG supramodule, formed by PDZ3, SH3, and Guanylate Kinase domain...

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Bibliographic Details
Main Authors: George L Hamilton, Nabanita Saikia, Sujit Basak, Franceine S Welcome, Fang Wu, Jakub Kubiak, Changcheng Zhang, Yan Hao, Claus AM Seidel, Feng Ding, Hugo Sanabria, Mark E Bowen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-09-01
Series:eLife
Subjects:
protein dynamics
single molecule fluorescence
postsynaptic density
FRET
discrete molecular dynamics simulations
Online Access:https://elifesciences.org/articles/77242

Internet

https://elifesciences.org/articles/77242

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