Pharmacokinetics and Pharmacodynamics of Colistin Combined With Isopropoxy Benzene Guanidine Against mcr-1-Positive Salmonella in an Intestinal Infection Model

Pharmacokinetics and Pharmacodynamics of Colistin Combined With Isopropoxy Benzene Guanidine Against mcr-1-Positive Salmonella in an Intestinal Infection Model

Plasmid-borne colistin resistance mediated by mcr-1 is a growing problem, which poses a serious challenge to the clinical application of colistin for Gram-negative bacterial infections. Drug combination is one of the effective strategies to treat colistin-resistant bacteria. Here, we found a guanidi...

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Bibliographic Details
Main Authors: Lingli Kong, Yixing Lu, Liuye Yang, Wanying Zhang, Beini Zuo, Xianfeng Peng, Zonghua Qin, Miao Li, Zhenling Zeng, Dongping Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Microbiology
Subjects:
colistin
isopropoxy benzene guanidine
pharmacokinetic/pharmacodynamic (PK/PD)
intestinal infection model
mcr-1
Salmonella
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.907116/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2022.907116/full

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