CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganizationResearch in context

CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganizationResearch in context

Summary: Background: Human restricted genes contribute to human specific traits in the immune system. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), the highest Ca2+ conductor of the ACh receptors implicated in innate immunity....

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Bibliographic Details
Main Authors: Kinga Szigeti, Ivanna Ihnatovych, Emily Notari, Ryu P. Dorn, Ivan Maly, Muye He, Barbara Birkaya, Shreyas Prasad, Robin Schwartz Byrne, Dinesh C. Indurthi, Erik Nimmer, Yuna Heo, Kolos Retfalvi, Lee Chaves, Norbert Sule, Wilma A. Hofmann, Anthony Auerbach, Gregory Wilding, Yongho Bae, Jessica Reynolds
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:EBioMedicine
Subjects:
Human immune diversity
CHRFAM7A
Ca2+ signalling
Actin cytoskeleton
Adaptation to the mechanical properties
Translational significance
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424001282

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http://www.sciencedirect.com/science/article/pii/S2352396424001282

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