Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

The blood system is supported by hematopoietic stem and progenitor cells (HSPCs) found in a specialized microenvironment called the niche. Many different niche cell types support HSPCs, however how they interact and their ultrastructure has been difficult to define. Here, we show that single endogen...

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Bibliographic Details
Main Authors: Sobhika Agarwala, Keun-Young Kim, Sebastien Phan, Saeyeon Ju, Ye Eun Kong, Guillaume A Castillon, Eric A Bushong, Mark H Ellisman, Owen J Tamplin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
hematopoietic stem cell
stem cell niche
microenvironment
light sheet microscopy
dopamine beta-hydroxylase
serial section block-face scanning electron microscopy
Online Access:https://elifesciences.org/articles/64835

Internet

https://elifesciences.org/articles/64835

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