Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features

Downregulation and Hypermethylation of GABPB1 Is Associated with Aggressive Thyroid Cancer Features

Promoter mutations of the telomerase reverse transcriptase (<i>TERT</i>) gene occur frequently in thyroid carcinoma (TC), including papillary (PTC) and anaplastic subtypes (ATC). Given that the ETS family transcription factors GABPA and GABPB1 activate the mutant <i>TERT</i>...

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Bibliographic Details
Main Authors: Xiangling Xing, Ninni Mu, Xiaotian Yuan, Na Wang, C. Christofer Juhlin, Klas Strååt, Catharina Larsson, Shi Yong Neo, Dawei Xu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
GABPA
GABPB1
DNA methylation
telomerase
TERT
thyroid carcinoma
Online Access:https://www.mdpi.com/2072-6694/14/6/1385

Internet

https://www.mdpi.com/2072-6694/14/6/1385

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