GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice

GBA1 inactivation in oligodendrocytes affects myelination and induces neurodegenerative hallmarks and lipid dyshomeostasis in mice

Abstract Background Mutations in the β-glucocerebrosidase (GBA1) gene do cause the lysosomal storage Gaucher disease (GD) and are among the most frequent genetic risk factors for Parkinson’s disease (PD). So far, studies on both neuronopathic GD and PD primarily focused on neuronal manifestations, b...

Full description

Bibliographic Details
Main Authors: Ilaria Gregorio, Loris Russo, Enrica Torretta, Pietro Barbacini, Gabriella Contarini, Giada Pacinelli, Dario Bizzotto, Manuela Moriggi, Paola Braghetta, Francesco Papaleo, Cecilia Gelfi, Enrico Moro, Matilde Cescon
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Molecular Neurodegeneration
Subjects:
Parkinson’s disease
Gaucher disease
Oligodendrocyte
White matter
β-glucocerebrosidase
Myelination
Online Access:https://doi.org/10.1186/s13024-024-00713-z

Internet

https://doi.org/10.1186/s13024-024-00713-z

Similar Items