A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1

A viral-fusion-peptide-like molecular switch drives membrane insertion of botulinum neurotoxin A1

The translocation domain (HN) of Botulinum neurotoxins (BoNTs) mediates the delivery of the BoNT light chain (LC) into neuronal cytosol. Here the authors provide insights into HN membrane insertion by determining the crystal structure of BoNT/A1 HN at acidic pH, which reveals a molecular switch in H...

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Bibliographic Details
Main Authors: Kwok-ho Lam, Zhuojun Guo, Nadja Krez, Tsutomu Matsui, Kay Perry, Jasmin Weisemann, Andreas Rummel, Mark E. Bowen, Rongsheng Jin
Format: Article
Language:English
Published: Nature Portfolio 2018-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07789-4

Internet

https://doi.org/10.1038/s41467-018-07789-4

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