Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression

Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression

Sigma σ1 and σ2 receptors are targets of cocaine. Despite sharing a similar name, the two receptors are structurally unrelated and their physiological role is unknown. Cocaine increases the level of dopamine, a key neurotransmitter in CNS motor control and reward areas. While the drug also affects d...

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Bibliographic Details
Main Authors: David Aguinaga, Mireia Medrano, Ignacio Vega-Quiroga, Katia Gysling, Enric I. Canela, Gemma Navarro, Rafael Franco
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
acute
addiction
cAMP
chronic
dopamine D1 and D2 receptors
ERK1/2 phosphorylation
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2018.00017/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2018.00017/full

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