Interaction of a Homologous Series of Amphiphiles with P-glycoprotein in a Membrane Environment—Contributions of Polar and Non-Polar Interactions

Interaction of a Homologous Series of Amphiphiles with P-glycoprotein in a Membrane Environment—Contributions of Polar and Non-Polar Interactions

The transport of drugs by efflux transporters in biomembranes limits their bioavailability and is a major determinant of drug resistance development by cancer cells and pathogens. A large number of chemically dissimilar drugs are transported, and despite extensive studies, the molecular determinants...

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Bibliographic Details
Main Authors: Maria João Moreno, Hugo A. L. Filipe, Susana V. P. Cunha, Cristiana V. Ramos, Patrícia A. T. Martins, Biebele Abel, Luís M. S. Loura, Suresh V. Ambudkar
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
efflux transporters
MDR1
ABCB1
pharmacokinetics
MD simulations
partition coefficient
Online Access:https://www.mdpi.com/1999-4923/15/1/174

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https://www.mdpi.com/1999-4923/15/1/174

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