Effects of H2O2 Treatment Combined With PI3K Inhibitor and MEK Inhibitor in AGS Cells: Oxidative Stress Outcomes in a Model of Gastric Cancer

Effects of H2O2 Treatment Combined With PI3K Inhibitor and MEK Inhibitor in AGS Cells: Oxidative Stress Outcomes in a Model of Gastric Cancer

Gastric cancer is worldwide the fifth and third cancer for incidence and mortality, respectively. Stomach wall is daily exposed to oxidative stress and BER system has a key role in the defense from oxidation-induced DNA damage, whilst ErbB receptors have important roles in the pathogenesis of cancer...

Full description

Bibliographic Details
Main Authors: Luca Savino, Maria Carmela Di Marcantonio, Carmelo Moscatello, Roberto Cotellese, Lucia Centurione, Raffaella Muraro, Gitana Maria Aceto, Gabriella Mincione
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Oncology
Subjects:
gastric cancer
ErbB receptors
reactive oxygen species
base excision repair system
PI3K and MAPK inhibitors
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.860760/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.860760/full

Similar Items