Inhibition of NF-κB and AP-1 by dimethylfumarate correlates with down-regulated IL-6 secretion and proliferation in human lung fibroblasts

Inhibition of NF-κB and AP-1 by dimethylfumarate correlates with down-regulated IL-6 secretion and proliferation in human lung fibroblasts

QUESTION UNDER STUDY/PRINCIPLES: Dimethylfumarate (DMF) had been reported to reduce asthma symptoms and to improve the quality of life of asthma patients. Therefore, we assessed the anti-inflammatory and anti-remodeling effect of DMF on isolated lung fibroblasts, which are relevant to inflammat...

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Bibliographic Details
Main Authors: P Seidel, I Merfort
Format: Article
Language:English
Published: SMW supporting association (Trägerverein Swiss Medical Weekly SMW) 2010-12-01
Series:Swiss Medical Weekly
Subjects:
anti-proliferative
AP-1
DMF
IL-6
inflammatory lung diseases
NF-κB
Online Access:https://www.smw.ch/index.php/smw/article/view/1225

Internet

https://www.smw.ch/index.php/smw/article/view/1225

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