Blocking TRAIL-DR5 signaling pathway with soluble death receptor 5 fusion protein mitigates radiation-induced injury

Blocking TRAIL-DR5 signaling pathway with soluble death receptor 5 fusion protein mitigates radiation-induced injury

The increasing application of nuclear technology, the high fatality of acute radiation syndrome (ARS) and its complex mechanism make ARS a global difficulty that requires urgent attention. Here we reported that the death receptor 5 (DR5), as well as its ligand tumor necrosis factor-related apoptosis...

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Bibliographic Details
Main Authors: Danyang Zhao, Lei Yang, Peng Han, Haihui Zhang, Fanjun Wang, Zhiyun Meng, Hui Gan, Zhuona Wu, Wenzhong Sun, Chuan Chen, Guifang Dou, Ruolan Gu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
DR5
TRAIL
ARS
apoptosis antagonist
radiation damage effect
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1171293/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1171293/full

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