Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

Summary: Sensing of cytoplasmic DNA by cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) results in production of the dinucleotide cGAMP and consecutive activation of stimulator of interferon genes (STING) followed by production of type I interferon (IFN). Although cance...

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Bibliographic Details
Main Authors: Linda Schadt, Colin Sparano, Nicole Angelika Schweiger, Karina Silina, Virginia Cecconi, Giulia Lucchiari, Hideo Yagita, Emilien Guggisberg, Sascha Saba, Zuzana Nascakova, Winfried Barchet, Maries van den Broek
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719312628

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http://www.sciencedirect.com/science/article/pii/S2211124719312628

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