GABAergic neurons differentiated from BDNF- and Dlx2-modified neural stem cells restore disrupted neural circuits in brainstem stroke

GABAergic neurons differentiated from BDNF- and Dlx2-modified neural stem cells restore disrupted neural circuits in brainstem stroke

Abstract Background Brainstem stroke causes severe and persistent neurological impairment. Due to the limited spontaneous recovery and regeneration of the disrupted neural circuits, transplantation of exogenous neural stem cells (NSCs) was an alternative, while there were limitations for primitive N...

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Bibliographic Details
Main Authors: Xiangyue Tang, Li Wu, Juehua Zhu, Mindong Xu, Shaojun Li, Guanfeng Zeng, Shuanggen Zhu, Yongjun Jiang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Stem Cell Research & Therapy
Subjects:
Brainstem
Stroke
Neural stem cells
Brain-derived neurotrophic factor
Dlx2
GABAergic
Online Access:https://doi.org/10.1186/s13287-023-03378-5

Internet

https://doi.org/10.1186/s13287-023-03378-5

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