AID/APOBEC cytosine deaminase induces genome-wide kataegis
<p>Abstract</p> <p>Clusters of localized hypermutation in human breast cancer genomes, named “kataegis” (from the Greek for thunderstorm), are hypothesized to result from multiple cytosine deaminations catalyzed by AID/APOBEC proteins. However, a direct link between APOBECs and kat...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-12-01
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| Series: | Biology Direct |
| Subjects: | |
| Online Access: | http://www.biology-direct.com/content/7/1/47 |
| _version_ | 1818778320376954880 |
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| author | Lada Artem G Dhar Alok Boissy Robert J Hirano Masayuki Rubel Aleksandr A Rogozin Igor B Pavlov Youri I |
| author_facet | Lada Artem G Dhar Alok Boissy Robert J Hirano Masayuki Rubel Aleksandr A Rogozin Igor B Pavlov Youri I |
| author_sort | Lada Artem G |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Clusters of localized hypermutation in human breast cancer genomes, named “kataegis” (from the Greek for thunderstorm), are hypothesized to result from multiple cytosine deaminations catalyzed by AID/APOBEC proteins. However, a direct link between APOBECs and kataegis is still lacking. We have sequenced the genomes of yeast mutants induced in diploids by expression of the gene for PmCDA1, a hypermutagenic deaminase from sea lamprey. Analysis of the distribution of 5,138 induced mutations revealed localized clusters very similar to those found in tumors. Our data provide evidence that unleashed cytosine deaminase activity is an evolutionary conserved, prominent source of genome-wide kataegis events.</p> <p>Reviewers</p> <p>This article was reviewed by: Professor Sandor Pongor, Professor Shamil R. Sunyaev, and Dr Vladimir Kuznetsov.</p> |
| first_indexed | 2024-12-18T11:42:51Z |
| format | Article |
| id | doaj.art-255890a64e474f3398670bbcac7943f5 |
| institution | Directory Open Access Journal |
| issn | 1745-6150 |
| language | English |
| last_indexed | 2024-12-18T11:42:51Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Biology Direct |
| spelling | doaj.art-255890a64e474f3398670bbcac7943f52022-12-21T21:09:23ZengBMCBiology Direct1745-61502012-12-01714710.1186/1745-6150-7-47AID/APOBEC cytosine deaminase induces genome-wide kataegisLada Artem GDhar AlokBoissy Robert JHirano MasayukiRubel Aleksandr ARogozin Igor BPavlov Youri I<p>Abstract</p> <p>Clusters of localized hypermutation in human breast cancer genomes, named “kataegis” (from the Greek for thunderstorm), are hypothesized to result from multiple cytosine deaminations catalyzed by AID/APOBEC proteins. However, a direct link between APOBECs and kataegis is still lacking. We have sequenced the genomes of yeast mutants induced in diploids by expression of the gene for PmCDA1, a hypermutagenic deaminase from sea lamprey. Analysis of the distribution of 5,138 induced mutations revealed localized clusters very similar to those found in tumors. Our data provide evidence that unleashed cytosine deaminase activity is an evolutionary conserved, prominent source of genome-wide kataegis events.</p> <p>Reviewers</p> <p>This article was reviewed by: Professor Sandor Pongor, Professor Shamil R. Sunyaev, and Dr Vladimir Kuznetsov.</p>http://www.biology-direct.com/content/7/1/47APOBECDeaminaseMutationKataegisCancerDiploid yeastHypermutation |
| spellingShingle | Lada Artem G Dhar Alok Boissy Robert J Hirano Masayuki Rubel Aleksandr A Rogozin Igor B Pavlov Youri I AID/APOBEC cytosine deaminase induces genome-wide kataegis Biology Direct APOBEC Deaminase Mutation Kataegis Cancer Diploid yeast Hypermutation |
| title | AID/APOBEC cytosine deaminase induces genome-wide kataegis |
| title_full | AID/APOBEC cytosine deaminase induces genome-wide kataegis |
| title_fullStr | AID/APOBEC cytosine deaminase induces genome-wide kataegis |
| title_full_unstemmed | AID/APOBEC cytosine deaminase induces genome-wide kataegis |
| title_short | AID/APOBEC cytosine deaminase induces genome-wide kataegis |
| title_sort | aid apobec cytosine deaminase induces genome wide kataegis |
| topic | APOBEC Deaminase Mutation Kataegis Cancer Diploid yeast Hypermutation |
| url | http://www.biology-direct.com/content/7/1/47 |
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