Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding

Ciliary Rab28 and the BBSome negatively regulate extracellular vesicle shedding

Cilia both receive and send information, the latter in the form of extracellular vesicles (EVs). EVs are nano-communication devices that influence cell, tissue, and organism behavior. Mechanisms driving ciliary EV biogenesis are almost entirely unknown. Here, we show that the ciliary G-protein Rab28...

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Bibliographic Details
Main Authors: Jyothi S Akella, Stephen P Carter, Ken Nguyen, Sofia Tsiropoulou, Ailis L Moran, Malan Silva, Fatima Rizvi, Breandan N Kennedy, David H Hall, Maureen M Barr, Oliver E Blacque
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-02-01
Series:eLife
Subjects:
cilia
Rab28
PKD2
extracellular vesicles
BBSome
ciliopathy
Online Access:https://elifesciences.org/articles/50580

Internet

https://elifesciences.org/articles/50580

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