Xenon’s Sedative Effect Is Mediated by Interaction with the Cyclic Nucleotide-Binding Domain (CNBD) of HCN2 Channels Expressed by Thalamocortical Neurons of the Ventrobasal Nucleus in Mice

Xenon’s Sedative Effect Is Mediated by Interaction with the Cyclic Nucleotide-Binding Domain (CNBD) of HCN2 Channels Expressed by Thalamocortical Neurons of the Ventrobasal Nucleus in Mice

Previous studies have shown that xenon reduces hyperpolarization-activated cyclic nucleotide-gated channels type-2 (HCN2) channel-mediated current (I<sub><i>h</i></sub>) amplitude and shifts the half-maximal activation voltage (<inline-formula><math xmlns="http:...

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Bibliographic Details
Main Authors: Nour El Dine Kassab, Verena Mehlfeld, Jennifer Kass, Martin Biel, Gerhard Schneider, Gerhard Rammes
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
xenon
anesthesia
electrophysiology
cyclic nucleotide-binding domain (CNBD)
hyperpolarization-activated cyclic nucleotide-gated type-2 (HCN2)
ventrobasal thalamus (VB)
Online Access:https://www.mdpi.com/1422-0067/24/10/8613

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https://www.mdpi.com/1422-0067/24/10/8613

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