The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice

The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in mice

Hematopoietic stem cells require MLL1, which is one of six Set1/Trithorax-type histone 3 lysine 4 (H3K4) methyltransferases in mammals and clinically the most important leukemia gene. Here, we add to emerging evidence that all six H3K4 methyltransferases play essential roles in the hematopoietic sys...

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Bibliographic Details
Main Authors: Kerstin Schmidt, Qinyu Zhang, Alpaslan Tasdogan, Andreas Petzold, Andreas Dahl, Borros M Arneth, Robert Slany, Hans Jörg Fehling, Andrea Kranz, Adrian Francis Stewart, Konstantinos Anastassiadis
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
Setd1b
H3K4 methylation
hematopoietic stem and progenitor cells
conditional mutagenesis
Online Access:https://elifesciences.org/articles/27157

Internet

https://elifesciences.org/articles/27157

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