Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells

Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells

Abstract Background The p73 protein is a tumor suppressor that shares structural and functional similarity with p53. p73 is expressed in two major isoforms; the TA isoform that interacts with p53 pathway, thus acting as tumor suppressor and the N-terminal truncated ΔN isoform that inhibits TAp73 and...

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Bibliographic Details
Main Authors: Alicja Sznarkowska, Anna Kostecka, Anna Kawiak, Pilar Acedo, Mattia Lion, Alberto Inga, Joanna Zawacka-Pankau
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Cell Division
Subjects:
TAp73
Protoporphyrin IX
Apoptosis
Yeast-based assay
MDM2
MDMX
Online Access:http://link.springer.com/article/10.1186/s13008-018-0043-3

Internet

http://link.springer.com/article/10.1186/s13008-018-0043-3

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