Lipofuscin Granule Bisretinoid Oxidation in the Human Retinal Pigment Epithelium forms Cytotoxic Carbonyls

Lipofuscin Granule Bisretinoid Oxidation in the Human Retinal Pigment Epithelium forms Cytotoxic Carbonyls

Age-related macular degeneration (AMD) is the primary cause of central blindness among the elderly. AMD is associated with progressive accumulation of lipofuscin granules in retinal pigment epithelium (RPE) cells. Lipofuscin contains bisretinoid fluorophores, which are photosensitizers and are photo...

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Bibliographic Details
Main Authors: Marina Yakovleva, Alexander Dontsov, Natalia Trofimova, Natalia Sakina, Alexey Kononikhin, Arseny Aybush, Alexander Gulin, Tatiana Feldman, Mikhail Ostrovsky
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
age-related macular degeneration
retinal pigment epithelium
lipofuscin granules
bisretinoid fluorophores
bisretinoid oxidation products
cytotoxic carbonyls
Online Access:https://www.mdpi.com/1422-0067/23/1/222

Internet

https://www.mdpi.com/1422-0067/23/1/222

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