Multi-ancestry epigenome-wide analyses identify methylated sites associated with aortic augmentation index in TOPMed MESA

Multi-ancestry epigenome-wide analyses identify methylated sites associated with aortic augmentation index in TOPMed MESA

Abstract Despite the prognostic value of arterial stiffness (AS) and pulsatile hemodynamics (PH) for cardiovascular morbidity and mortality, epigenetic modifications that contribute to AS/PH remain unknown. To gain a better understanding of the link between epigenetics (DNA methylation) and AS/PH, w...

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Bibliographic Details
Main Authors: Xiaowei Hu, Jeongok G. Logan, Younghoon Kwon, Joao A. C. Lima, David R. Jacobs, Daniel Duprez, Lyndia Brumback, Kent D. Taylor, Peter Durda, W. Craig Johnson, Elaine Cornell, Xiuqing Guo, Yongmei Liu, Russell P. Tracy, Thomas W. Blackwell, George Papanicolaou, Gary F. Mitchell, Stephen S. Rich, Jerome I. Rotter, David J. Van Den Berg, Julio A. Chirinos, Timothy M. Hughes, Francine E. Garrett-Bakelman, Ani Manichaikul
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-44806-z

Internet

https://doi.org/10.1038/s41598-023-44806-z

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