Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion

Circ VRK1/microRNA-17/PTEN axis modulates the angiogenesis of human brain microvascular endothelial cells to affect injury induced by oxygen-glucose deprivation/reperfusion

Abstract Background Circular RNAs (circRNAs) can act as microRNA (miRNA) sponges, thus regulating gene expression. The role of circRNAs in the process of oxygen-glucose deprivation/reoxygenation (OGD/R) is unclear. Here, we explored the mechanism underlying Circ VRK1 in human brain microvascular end...

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Bibliographic Details
Main Authors: Lei Yang, Hong Du, Xuejing Zhang, Bulang Gao, Dongliang Zhang, Zongrong Qiao, Xianhui Su, Tong Bao, Siqin Han
Format: Article
Language:English
Published: BMC 2023-01-01
Series:BMC Neuroscience
Subjects:
Circ VRK1
microRNA-17
PTEN
PI3K/AKT pathway
Oxygen-glucose deprivation/reoxygenation
Online Access:https://doi.org/10.1186/s12868-023-00774-8

Internet

https://doi.org/10.1186/s12868-023-00774-8

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