Preparation of Tryptanthrin Derivates Bearing a Thiosemicarbazone Moiety to Inhibit SARS-CoV-2 Replication

Preparation of Tryptanthrin Derivates Bearing a Thiosemicarbazone Moiety to Inhibit SARS-CoV-2 Replication

SARS-CoV-2 is a serious viral pathogen, and agents that inhibit its replication are in high demand. In the present work, we prepared two novel tryptanthrin derivates bearing a thiosemicarbazone moiety as potential antiviral agents. Both compounds displayed potent chelation activity against Fe(III/II...

Full description

Bibliographic Details
Main Authors: Kateřina Veselá, Zora Mělková, Nikita Abramenko, Zdeněk Kejík, Robert Kaplánek, Petr Dytrych, Alla Sinica, Oleksandra Vozniuk, Pavel Martásek, Milan Jakubek
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Separations
Subjects:
tryptanthrin
phaitanthrin A
thiosemicarbazone
SARS-CoV-2
antiviral
chelation
Online Access:https://www.mdpi.com/2297-8739/10/2/73

Internet

https://www.mdpi.com/2297-8739/10/2/73

Similar Items