Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice

Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice

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Millions of patients suffer from silicosis, but it remains an uncurable disease due to its unclear pathogenic mechanisms. Though the Nlrp3 inflammasome is involved in silicosis pathogenesis, inhibition of its classic downstream factors, Caspase-1 and Gsdmd, fails to block pyroptosis and cytokine rel...

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Bibliographic Details
Main Authors: Lulu Kang, Jinghong Dai, Yufang Wang, Peiliang Shi, Yujie Zou, Jingwen Pei, Yaqiong Tian, Ji Zhang, Visarut Codey Buranasudja, Jingyu Chen, Hourong Cai, Xiang Gao, Zhaoyu Lin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-12-01
Series:PLoS Genetics
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718385/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718385/?tool=EBI

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