Antioxidant PDA-PEG nanoparticles alleviate early osteoarthritis by inhibiting osteoclastogenesis and angiogenesis in subchondral bone

Antioxidant PDA-PEG nanoparticles alleviate early osteoarthritis by inhibiting osteoclastogenesis and angiogenesis in subchondral bone

Abstract Accumulating evidence suggests that osteoclastogenesis and angiogenesis in subchondral bone are critical destructive factors in the initiation and progression of osteoarthritis (OA). Herein, methoxypolyethylene glycol amine (mPEG-NH2) modified polydopamine nanoparticles (PDA-PEG NPs) were s...

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Bibliographic Details
Main Authors: Zhikai Wu, Kai Yuan, Qian Zhang, Jiong Jiong Guo, Huilin Yang, Feng Zhou
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Nanobiotechnology
Subjects:
PDA-PEG NPs
Osteoarthritis
Osteoclastogenesis
Angiogenesis
ROS
PDGF-BB
Online Access:https://doi.org/10.1186/s12951-022-01697-y

Internet

https://doi.org/10.1186/s12951-022-01697-y

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