DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes.

DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes.

Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity in mammals results in severe combined immuno-deficiency (SCID). This SCID phenotype has been postulated to be due solely to the function of DNA-PKcs in V(D)J recombination, a process critical for lymphocyte maturation. Howeve...

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Bibliographic Details
Main Authors: Ara Kim Wiese, Marie Schluterman Burdine, Richard H Turnage, Alan J Tackett, Lyle J Burdine
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5531461?pdf=render

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http://europepmc.org/articles/PMC5531461?pdf=render

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