QS21-Initiated Fusion of Liposomal Small Unilamellar Vesicles to Form ALFQ Results in Concentration of Most of the Monophosphoryl Lipid A, QS21, and Cholesterol in Giant Unilamellar Vesicles

QS21-Initiated Fusion of Liposomal Small Unilamellar Vesicles to Form ALFQ Results in Concentration of Most of the Monophosphoryl Lipid A, QS21, and Cholesterol in Giant Unilamellar Vesicles

Army Liposome Formulation with QS21 (ALFQ), a vaccine adjuvant preparation, comprises liposomes containing saturated phospholipids, with 55 mol% cholesterol relative to the phospholipids, and two adjuvants, monophosphoryl lipid A (MPLA) and QS21 saponin. A unique feature of ALFQ is the formation of...

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Bibliographic Details
Main Authors: Erwin G. Abucayon, Mangala Rao, Gary R. Matyas, Carl R. Alving
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Pharmaceutics
Subjects:
giant unilamellar vesicle
vaccine adjuvant
monophosphoryl lipid A
cholesterol
QS21
QS-21
Online Access:https://www.mdpi.com/1999-4923/15/9/2212

Internet

https://www.mdpi.com/1999-4923/15/9/2212

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