Enhanced Virus Detection and Metagenomic Sequencing in Patients with Meningitis and Encephalitis

Enhanced Virus Detection and Metagenomic Sequencing in Patients with Meningitis and Encephalitis

ABSTRACT Meningitis and encephalitis are leading causes of central nervous system (CNS) disease and often result in severe neurological compromise or death. Traditional diagnostic workflows largely rely on pathogen-specific tests, sometimes over days to weeks, whereas metagenomic next-generation seq...

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Bibliographic Details
Main Authors: Anne Piantadosi, Shibani S. Mukerji, Simon Ye, Michael J. Leone, Lisa M. Freimark, Daniel Park, Gordon Adams, Jacob Lemieux, Sanjat Kanjilal, Isaac H. Solomon, Asim A. Ahmed, Robert Goldstein, Vijay Ganesh, Bridget Ostrem, Kaelyn C. Cummins, Jesse M. Thon, Cormac M. Kinsella, Eric Rosenberg, Matthew P. Frosch, Marcia B. Goldberg, Tracey A. Cho, Pardis Sabeti
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mBio
Subjects:
encephalitis
metagenomic sequencing
next-generation sequencing (NGS)
meningitis
virus
hybrid capture
Online Access:https://journals.asm.org/doi/10.1128/mBio.01143-21

Internet

https://journals.asm.org/doi/10.1128/mBio.01143-21

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