Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro

Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro

Abstract Background Sporozoites (SPZ), the infective form of Plasmodium falciparum malaria, can be inoculated into the human host skin by Anopheline mosquitoes. These SPZ migrate at approximately 1 µm/s to find a blood vessel and travel to the liver where they infect hepatocytes and multiply. In the...

Full description

Bibliographic Details
Main Authors: Roos van Schuijlenburg, Samaneh Azargoshasb, Clarize M. de Korne, Jeroen C. Sijtsma, Sascha Bezemer, Alwin J. van der Ham, Els Baalbergen, Fiona Geurten, Laura M. de Bes-Roeleveld, Severine C. Chevalley-Maurel, Matthias N. van Oosterom, Fijs W. B. van Leeuwen, Blandine Franke-Fayard, Meta Roestenberg
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum
Sporozoites
Motility
Immunogenicity
Online Access:https://doi.org/10.1186/s12936-024-04946-7

Internet

https://doi.org/10.1186/s12936-024-04946-7

Similar Items