Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro

Ageing of Plasmodium falciparum malaria sporozoites alters their motility, infectivity and reduces immune activation in vitro

Abstract Background Sporozoites (SPZ), the infective form of Plasmodium falciparum malaria, can be inoculated into the human host skin by Anopheline mosquitoes. These SPZ migrate at approximately 1 µm/s to find a blood vessel and travel to the liver where they infect hepatocytes and multiply. In the...

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Bibliografiska uppgifter
Huvudupphovsmän: Roos van Schuijlenburg, Samaneh Azargoshasb, Clarize M. de Korne, Jeroen C. Sijtsma, Sascha Bezemer, Alwin J. van der Ham, Els Baalbergen, Fiona Geurten, Laura M. de Bes-Roeleveld, Severine C. Chevalley-Maurel, Matthias N. van Oosterom, Fijs W. B. van Leeuwen, Blandine Franke-Fayard, Meta Roestenberg
Materialtyp: Artikel
Språk:English
Publicerad: BMC 2024-04-01
Serie:Malaria Journal
Ämnen:
Malaria
Plasmodium falciparum
Sporozoites
Motility
Immunogenicity
Länkar:https://doi.org/10.1186/s12936-024-04946-7

Internet

https://doi.org/10.1186/s12936-024-04946-7

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