Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the App NL−F/NL−F knock-in mouse model of Alzheimer’s disease

Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the App NL−F/NL−F knock-in mouse model of Alzheimer’s disease

Abstract Background Aβ42/Aβ40 ratios in cerebrospinal fluid (CSF) and blood are reduced in preclinical Alzheimer’s disease (AD), but their temporal and correlative relationship with cerebral Aβ pathology at this early disease stage is not well understood. In the present study, we aim to investigate...

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Bibliographic Details
Main Authors: Emelie Andersson, Nina Schultz, Takashi Saito, Takaomi C. Saido, Kaj Blennow, Gunnar K. Gouras, Henrik Zetterberg, Oskar Hansson
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Biomarker
Cerebrospinal fluid
Blood
Beta-amyloid
Online Access:https://doi.org/10.1186/s13195-023-01196-8

Internet

https://doi.org/10.1186/s13195-023-01196-8

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