IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response

IκB Kinase ε Is an NFATc1 Kinase that Inhibits T Cell Immune Response

Activation of nuclear factor of activated T cells (NFAT) is crucial for immune responses. IKKε is an IκB kinase (IKK)-related kinase, and the function of IKKε remains obscure in T cells, despite its abundant expression. We report that IKKε inhibits NFAT activation and T cell responses by promoting N...

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Bibliographic Details
Main Authors: Junjie Zhang, Hao Feng, Jun Zhao, Emily R. Feldman, Si-Yi Chen, Weiming Yuan, Canhua Huang, Omid Akbari, Scott A. Tibbetts, Pinghui Feng
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306969

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http://www.sciencedirect.com/science/article/pii/S2211124716306969

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