The New Generation <i>h</i>DHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses

The New Generation <i>h</i>DHODH Inhibitor MEDS433 Hinders the In Vitro Replication of SARS-CoV-2 and Other Human Coronaviruses

Although coronaviruses (CoVs) have long been predicted to cause zoonotic diseases and pandemics with high probability, the lack of effective anti-pan-CoVs drugs rapidly usable against the emerging SARS-CoV-2 actually prevented a promptly therapeutic intervention for COVID-19. Development of host-tar...

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Bibliographic Details
Main Authors: Arianna Calistri, Anna Luganini, Barbara Mognetti, Elizabeth Elder, Giulia Sibille, Valeria Conciatori, Claudia Del Vecchio, Stefano Sainas, Donatella Boschi, Nuria Montserrat, Ali Mirazimi, Marco Lucio Lolli, Giorgio Gribaudo, Cristina Parolin
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Microorganisms
Subjects:
coronavirus
SARS-CoV-2
pyrimidine biosynthesis
<i>h</i>DHODH inhibitor
antiviral activity
combination treatment
Online Access:https://www.mdpi.com/2076-2607/9/8/1731

Internet

https://www.mdpi.com/2076-2607/9/8/1731

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