Arctium lappa leaves based on network pharmacology and experimental validation attenuate atherosclerosis by targeting the AMPK-mediated PPARG/LXRα pathway

Arctium lappa leaves based on network pharmacology and experimental validation attenuate atherosclerosis by targeting the AMPK-mediated PPARG/LXRα pathway

Arctium lappa (A. lappa) leaves are widely used in various traditional Chinese herbal formulae to ameliorate atherosclerosis (AS) and its complications such as stroke; however, there is no literature reporting the anti-atherosclerotic effect and mechanism of A. lappa leaves thus far. In the present...

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Bibliographic Details
Main Authors: Mengmeng Wang, Bingdi Cui, Man Gong, Qiuyan Liu, Xingxu Zhuo, Jiangnan Lv, Lianhe Yang, Xiaoqian Liu, Zhimin Wang, Liping Dai
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Arctium lappa leaves
Atherosclerosis
Cardiovascular disease
Cholesterol efflux
AMPK
PPARG/LXRα
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222008927

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http://www.sciencedirect.com/science/article/pii/S0753332222008927

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