The CSF1R-Microglia Axis Has Protective Host-Specific Roles During Neurotropic Picornavirus Infection

Viral encephalitis is a major cause of morbidity and mortality, but the manifestation of disease varies greatly between individuals even in response to the same virus. Microglia are professional antigen presenting cells that reside in the central nervous system (CNS) parenchyma that are poised to re...

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Bibliographic Details
Main Authors: John Michael S. Sanchez, Ana Beatriz DePaula-Silva, Daniel J. Doty, Tyler J. Hanak, Amanda Truong, Jane E. Libbey, Robert S. Fujinami
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.621090/full