An Anti-Inflammatory Azaphenothiazine Inhibits Interferon β Expression and CXCL10 Production in KERTr Cells

An Anti-Inflammatory Azaphenothiazine Inhibits Interferon β Expression and CXCL10 Production in KERTr Cells

An azaphenothiazine derivative, 6-chloroethylureidoethyldiquino[3,2-b;2′,3′-e][1,4]thiazine (DQT), has recently been shown to exhibit immunosuppressive activities in mouse models. It also inhibited the expression of CXCL10 at the protein level, at non-toxic concentrations, in the culture of KERTr ce...

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Bibliographic Details
Main Authors: Leon Strzadala, Anna Fiedorowicz, Edyta Wysokinska, Ewa Ziolo, Małgorzata Grudzień, Malgorzata Jelen, Krystian Pluta, Beata Morak-Mlodawska, Michal Zimecki, Wojciech Kalas
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
azaphenothiazine
anti-inflammatory activity
CXCL10
KERTr cells
keratinocytes
IFNβ
TLR3
Online Access:http://www.mdpi.com/1420-3049/23/10/2443

Internet

http://www.mdpi.com/1420-3049/23/10/2443

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