Loss of Sec-1 Family Domain-Containing 1 (<i>scfd1</i>) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish

Loss of Sec-1 Family Domain-Containing 1 (<i>scfd1</i>) Causes Severe Cardiac Defects and Endoplasmic Reticulum Stress in Zebrafish

Dilated cardiomyopathy (DCM) is a common heart muscle disorder that frequently leads to heart failure, arrhythmias, and death. While DCM is often heritable, disease-causing mutations are identified in only ~30% of cases. In a forward genetic mutagenesis screen, we identified a novel zebrafish mutant...

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Bibliographic Details
Main Authors: Inken G. Huttner, Celine F. Santiago, Arie Jacoby, Delfine Cheng, Gunjan Trivedi, Stephen Cull, Jasmina Cvetkovska, Renee Chand, Joachim Berger, Peter D. Currie, Kelly A. Smith, Diane Fatkin
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
dilated cardiomyopathy
genetics
<i>scfd1</i>
zebrafish
ER stress
protein homeostasis
Online Access:https://www.mdpi.com/2308-3425/10/10/408

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https://www.mdpi.com/2308-3425/10/10/408

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