Astragaloside IV improves slow transit constipation by regulating gut microbiota and enterochromaffin cells

Astragaloside IV improves slow transit constipation by regulating gut microbiota and enterochromaffin cells

Purpose: Slow transit constipation (STC) is a common gastrointestinal disorder characterized by altered gut microbiota and reduced number of enterochromaffin cells (ECs). Astragaloside IV (AS-IV), a low drug permeability saponin, has showed beneficial effects on patients with STC. However, the speci...

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Bibliographic Details
Main Authors: Xingyang Wan, Qian Zhou, Huaxian Chen, Zhen Li, Mianling Mo, Zhimin Liu, Heng Zhang, Zhuojie He, Guozhong Xiao, Yihui Zheng, Hongcheng Lin, Donglin Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
astragaloside IV
enterochromaffin cells
Piezo2
3-BrY
gut microbiota
slow transit constipation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1196210/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1196210/full

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