The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3

The Upregulation of Leucine-Rich Repeat Containing 1 Expression Activates Hepatic Stellate Cells and Promotes Liver Fibrosis by Stabilizing Phosphorylated Smad2/3

Liver fibrosis poses a significant global health risk due to its association with hepatocellular carcinoma (HCC) and the lack of effective treatments. Thus, the need to discover additional novel therapeutic targets to attenuate liver diseases is urgent. Leucine-rich repeat containing 1 (LRRC1) repor...

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Bibliographic Details
Main Authors: Yake Wang, Xiaolong Li, Xiaowen Guan, Zhe Song, Huanfei Liu, Zhenzhen Guan, Jianwei Wang, Lina Zhu, Di Zhang, Liang Zhao, Peitong Xie, Xiaoyi Wei, Ning Shang, Ying Liu, Zhongzhen Jin, Zhili Ji, Guifu Dai
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
liver fibrosis
LRRC1
p-Smad2/3
HSC activation
ubiquitination
Online Access:https://www.mdpi.com/1422-0067/25/5/2735

Internet

https://www.mdpi.com/1422-0067/25/5/2735

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