CD103 deficiency prevents graft-versus-host disease but spares graft-versus-tumor effects mediated by alloreactive CD8 T cells.

CD103 deficiency prevents graft-versus-host disease but spares graft-versus-tumor effects mediated by alloreactive CD8 T cells.

Graft-versus-host disease (GVHD) remains the main barrier to broader application of allogeneic hematopoietic stem cell transplantation (alloSCT) as a curative therapy for host malignancy. GVHD is mediated by allogeneic T cells directed against histocompatibility antigens expressed by host tissues. B...

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Bibliographic Details
Main Authors: Kechang Liu, Bryan A Anthony, Martha M Yearsly, Mehdi Hamadani, Alice Gaughan, Jiao-Jing Wang, Steven M Devine, Gregg A Hadley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3136479?pdf=render

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http://europepmc.org/articles/PMC3136479?pdf=render

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