Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function

Balancing WNT signalling in early forebrain development: The role of LRP4 as a modulator of LRP6 function

The specification of the forebrain relies on the precise regulation of WNT/ß-catenin signalling to support neuronal progenitor cell expansion, patterning, and morphogenesis. Imbalances in WNT signalling activity in the early neuroepithelium lead to congenital disorders, such as neural tube defects (...

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Bibliographic Details
Main Authors: Shuang Geng, Fabian Paul, Izabela Kowalczyk, Sandra Raimundo, Anje Sporbert, Tamrat Meshka Mamo, Annette Hammes
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
LRP4
forebrain
development
WNT pathway
genetic modifier
LRP6
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1173688/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1173688/full

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