The emerging importance of the α-keto acid dehydrogenase complexes in serving as intracellular and intercellular signaling platforms for the regulation of metabolism

The α-keto acid dehydrogenase complex (KDHc) class of mitochondrial enzymes is composed of four members: pyruvate dehydrogenase (PDHc), α-ketoglutarate dehydrogenase (KGDHc), branched-chain keto acid dehydrogenase (BCKDHc), and 2-oxoadipate dehydrogenase (OADHc). These enzyme complexes occupy critic...

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Bibliographic Details
Main Author: Ryan J. Mailloux
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724001319