Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis

Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis

Abstract Background Glioblastoma (GBM) is the most common malignant tumor of the central nervous system. It is an aggressive tumor characterized by rapid proliferation, diffuse tumor morphology, and poor prognosis. Unfortunately, current treatments, such as surgery, radiotherapy, and chemotherapy, a...

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Bibliographic Details
Main Authors: Jie Li, Bin Zhang, Zishan Feng, Dandan An, Zhiyuan Zhou, Chao Wan, Yan Hu, Yajie Sun, Yijun Wang, Xixi Liu, Wenwen Wei, Xiao Yang, Jingshu Meng, Mengjie Che, Yuhan Sheng, Bian Wu, Lu Wen, Fang Huang, Yan Li, Kunyu Yang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
KPNB1
Nuclear translocation
NLGN3
Glioblastoma
USP7
Deubiquitination
Online Access:https://doi.org/10.1186/s13046-024-02954-8

Internet

https://doi.org/10.1186/s13046-024-02954-8

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