Synthesis and In Vivo Antiarrhythmic Activity Evaluation of Novel Scutellarein Analogues as Voltage-Gated Nav1.5 and Cav1.2 Channels Blockers

Synthesis and In Vivo Antiarrhythmic Activity Evaluation of Novel Scutellarein Analogues as Voltage-Gated Nav1.5 and Cav1.2 Channels Blockers

Malignant cardiac arrhythmias with high morbidity and mortality have posed a significant threat to our human health. Scutellarein, a metabolite of Scutellarin which is isolated from <i>Scutellaria altissima</i> L., presents excellent therapeutic effects on cardiovascular diseases and cou...

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Bibliographic Details
Main Authors: Wei Yang, Wenping Wang, Song Cai, Peng Li, Die Zhang, Jinhua Ning, Jin Ke, Anguo Hou, Linyun Chen, Yunshu Ma, Wenbin Jin
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
antiarrhythmic
scutellarein derivatives
Nav1.5 channel blockers
Cav1.2 channel blockers
electrophysiology
Online Access:https://www.mdpi.com/1420-3049/28/21/7417

Internet

https://www.mdpi.com/1420-3049/28/21/7417

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