Improving Expression of Pepsinogen A from <i>Homo sapiens</i> in <i>Aspergillus niger</i> by Using a Multi-Copy Gene Knock-in Strategy
Pepsinogen A (PGA) plays an important role in the treatment of human gastrointestinal diseases. At present, PGA is mainly extracted from pig stomach, so its source is very limited and its price is very expensive. Production of PGA by microbial fermentation using an engineered strain with high PGA yi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
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| Series: | Fermentation |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-5637/9/6/538 |