Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation

Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation

AbstractAbnormal accumulation of branched-chain amino acids (BCAAs) can lead to metabolic diseases and cancers. Branched-chain α-keto acid dehydrogenase kinase (BCKDK) is a key negative regulator of BCAA catabolism, and targeting BCKDK provides a promising therapeutic approach for diseases caused by...

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Bibliographic Details
Main Authors: Chunqiong Li, Quanjun Yang, Li Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
BCKDK
allosteric inhibitors
virtual screening
BCAA metabolism
metabolic diseases and cancer treatment
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2290458

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2290458

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